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R/F-72
Comparative studies of macrophage function: Bivalve hemocyte chemiluminescence
Principal Investigator:
Robert S. AndersonStart/End Year:
1991 - 1994Institution:
Chesapeake Biological Laboratory, University of Maryland Center for Environmental ScienceTopic(s):
Description:
The main objective is to carry out comparative studies of the effects of metals and other chemicals on macrophage immune functions using mammalian and aquatic invertebrate animal models. This is part of a collaborative study to determine the potential for interspecies extrapolation of immunotoxicological data, in an attempt to develop models using alternative species for toxicity testing. Immunosuppressive effects of chemical exposure on bivalve blood cells (this proposal) will be compared to those produced by the same chemicals on rat alveolar macrophages (carried out by collaborators at the U.S. Army Chemical Research, Development and Engineering Center).
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Featured Fellow
Leone Yisrael is a cephalopod-loving scuba diver, cook, and loves to try new activities. She conducts genetic analysis and fieldwork at the Smithsonian Environmental Research Center through the Coastal Disease Ecology Lab.
Featured Research Project
Developing a habitat model for mysids, an important link in Chesapeake Bay food webs
Mysids are important mesozooplankton prey for many species of fish in Chesapeake Bay and are an important link in transferring energy from lower to upper trophic levels. Mysids also serve as biological vectors for benthic-pelagic coupling due to their diel vertical migration and omnivorous prey-switching behavior, which makes mysids important regulators of food web architecture. Despite their central role in coastal food webs, surprisingly little is known about mysid ecology and dynamics in Chesapeake Bay.
